Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
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چکیده
منابع مشابه
Markedly Elevated Carbamazepine-10,11-epoxide/Carbamazepine Ratio in a Fatal Carbamazepine Ingestion
Carbamazepine is a widely used anticonvulsant. Its metabolite, carbamazepine-10,11-epoxide, has been found to display similar anticonvulsant and neurotoxic properties. While the ratio of parent to metabolite concentration varies significantly, at therapeutic doses the epoxide concentration is generally about 20% of the parent. We report a case of fatal carbamazepine overdose in which the epoxid...
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High-resolution STM imaging of the structures formed by carbamazepine molecules adsorbed onto a pseudo-ordered carbamazepine monolayer on Au(111) shows the formation of previously unreported 1-dimensional supramolecular assemblies.
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BACKGROUND Combinations of olanzapine and carbamazepine are often used in clinical practice in the management of mania. AIMS To assess the efficacy and safety of olanzapine plus carbamazepine in mixed and manic bipolar episodes. METHOD Randomised, double-blind, 6-week trial of olanzapine (10-30 mg/day) plus carbamazepine (400-1200 mg/day; n=58) v. placebo plus carbamazepine (n=60) followed ...
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Carbamazepine oral suspension (100mg/5ml), 100mg and 200mg chewable tablets are proposed for addition to the Model List of Essential Medicines, for use in the management of epilepsy in children. It is at least as effective as phenobarbitone, phenytoin and sodium valproate in the management of partial and tonic-clonic seizures in children. Carbamazepine is available in the UK as a sugar free ora...
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OBJECTIVE Vitiligo is a rare side effect of carbamazepine whose exact mechanism is unknown. The aim of this report is to describe a single case of vitiligo induced by carbamazepine. METHODS The case was a patient with Bipolar I disorder whose medications were changed from valproate to carbamazepine and who developed vitiligo after a short while. We followed the case for about four years when ...
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ژورنال
عنوان ژورنال: Case Reports in Medicine
سال: 2015
ISSN: 1687-9627,1687-9635
DOI: 10.1155/2015/369707